2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2298A
    TAT-P4-(DATC5)2 TFA 98%
    TAT-P4-(DATC5)2 TFA is a high-affinity peptide inhibitor of the PICK1 (protein interacting with C kinase-1) PDZ domain, with a Ki of 1.7 nM. TAT-P4-(DATC5)2 TFA can inhibit addiction in rats.
    TAT-P4-(DATC5)2 TFA
  • HY-P2307A
    Tat-NR2Baa TFA 98%
    Tat-NR2BAA TFA is the control peptide of Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA TFA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable of binding PSD-95. Tat-NR2B9c is a membrane-permeant peptide and disrupts PSD-95/NMDAR binding, correlate with uncoupling NR2B- and/or NR2A-type NMDARs from PSD-95.
    Tat-NR2Baa TFA
  • HY-P2713A
    OM99-2 TFA 2504147-81-1 98%
    OM99-2 TFA, an eight residue peptidomimetic, tight-binding inhibitor of human brain memapsin 2 with a Ki value of 9.58 nM. OM99-2 TFA is significantly advanced the development of BACE1 inhibitor. OM99-2 has the potential for the research of the Alzheimer's disease.
    OM99-2 TFA
  • HY-P2786A
    Phrixotoxin 2 741738-57-8 98%
    Phrixotoxin 2 is a highly selective KV4.2 and KV4.3-channels blocker.
    Phrixotoxin 2
  • HY-P2812B
    Phospholipase D, cabbage 9001-87-0 98%
    Phospholipase D, cabbage is an enzyme of the phospholipase superfamily. Phospholipase D, cabbage is widely found in bacteria, yeast, plants, animals and viruses and is often used in biochemical research. Phospholipase D, cabbage can catalyze the hydrolysis of the phosphodiester bond of glycerophospholipids to produce phosphatidic acid and soluble choline. Phospholipase D, cabbage is involved in a variety of disease-related processes, including diabetes, atherosclerosis, obesity, tumorigenesis, immune response and neuroendocrine function.
    Phospholipase D, cabbage
  • HY-P3242A
    Mad1 (6-21) TFA 98%
    Mad1 (6-21) TFA is the 6-21 fragment of Mad1 protein. Mad1 (6-21) TFA binds to mammalian Sin3A PAH2 with a Kd of ~29 nM.
    Mad1 (6-21) TFA
  • HY-P3257A
    ADP-specific glucokinase, pyrococcus furiosus 173585-07-4 98%
    ADP-Specific glucokinase, pyrococcus furiosus is an ADP-specific glucose kinase expressed in thermophilic archaea. ADP-Specific glucokinase, pyrococcus furiosus can catalyze glucose into glucose-6-phosphate, which promotes glycolysis. ADP-Specific glucokinase, pyrococcus furiosus can activate T cells and enhance the phagocytic activity of macrophages. ADP-Specific glucokinase, pyrococcus furiosus can be used in research on metabolic diseases, neurological disorders, and tumors.
    ADP-specific glucokinase, pyrococcus furiosus
  • HY-P3257B
    ADP-Specific glucokinase, thermococcus litoralis 98%
    ADP-Specific glucokinase, thermococcus litoralis is an ADP-specific glucose kinase expressed in thermophilic archaea. ADP-Specific glucokinase, thermococcus litoralis can catalyze glucose into glucose-6-phosphate, which promotes glycolysis. ADP-Specific glucokinase, thermococcus litoralis can activate T cells and enhance the phagocytic activity of macrophages. ADP-Specific glucokinase, thermococcus litoralis can be used in research on metabolic diseases, neurological disorders, and tumors.
    ADP-Specific glucokinase, thermococcus litoralis
  • HY-P3446A
    Big Gastrin I (human) TFA 98%
    Big Gastrin I, human (TFA) is a gastrointestinal hormone consisting of 34 amino acids. Big Gastrin I, human (TFA) can be used as a potential substance for the study of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurological diseases or cardiovascular diseases.
    Big Gastrin I (human) TFA
  • HY-P3513A
    β-Neo-Endorphin acetate 78658-39-6 98%
    β-Neo-Endorphin acetate is an endogenous opioid peptide. β-Neo-Endorphin acetate is a hypothalamic "big" Leu-enkephalin of porcine origin. β-Neo-Endorphin acetate shows activation of the Erk1/2, MMP-2 and MMP-9.
    β-Neo-Endorphin acetate
  • HY-P3647A
    [DPro10] Dynorphin A (1-11), porcine hydrochloride 98%
    [DPro10] Dynorphin A (1-11), porcine hydrochloride, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine hydrochloride has analgesic property.
    [DPro10] Dynorphin A (1-11), porcine hydrochloride
  • HY-P3870B
    DALDA TFA 98%
    DALDA TFA is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA TFA shows antinociceptive and respiratory effects.
    DALDA TFA
  • HY-P4678A
    (Phe2,Orn8)-Oxytocin acetate 98%
    (Phe2,Orn8)-Oxytocin acetate is a selective V1 vasopressin agonist. (Phe2,Orn8)-Oxytocin acetate induces a sustained contractility of rabbit epididymis with EC50 value of 280 nM.
    (Phe2,Orn8)-Oxytocin acetate
  • HY-P5754A
    TAT-NEP1-40 TFA 98%
    TAT-NEP1-40 TFA is a BBB-penatrable peptide. TAT-NEP1-40 TFA protects PC12 cells against oxygen and glucose deprivation (OGD), and promotes neurite outgrowth. TAT-NEP1-40 TFA also improves ischemia-induced neurologic outcomes by inhibiting cell apoptosis in ischemic brains. TAT-NEP1-40 TFA can be used for research of CNS injuries, such as axonal regeneration and functional recovery after stroke.
    TAT-NEP1-40 TFA
  • HY-P5762A
    Phoenixin-14 TFA 98%
    Phoenixin-14 (PNX-14) TFA, a neuropeptide, has anxiolytic, cardioprotective and neuroprotective effect. Phoenixin-14 TFA can regulate pituitary gonadotrophin secretion by upregulating the GnRH receptor mRNA. Phoenixin-14 TFA stimulates insulin secretion. Phoenixin-14 TFA also protects mice from ischemia/reperfusion (IR) injury. PNX-14 TFA prevents oxidative stress by reducing ROS and increasing GSH.
    Phoenixin-14 TFA
  • HY-P5763A
    Phoenixin-20 TFA 98%
    Phoenixin-20 (TFA) (PNX-20 (TFA)) is a bioactive peptide with hormone-like actions in vertebrates, and can stimulates hypothalamo-pituitary-gonadal hormones and regulate reproductive processes in mammals. Phoenixin-20 (TFA) promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. Phoenixin-20 (TFA) has anxiolytic effect.
    Phoenixin-20 TFA
  • HY-P99448
    Atinumab 1226761-65-4
    Atinumab (6A3-IgG4) is an antibody. Teropavimab can be used for the research of spinal cord injury (SCI).
    Atinumab
  • HY-P99527
    Vanutide cridificar 886584-10-7
    Vanutide cridificar (ACC-001) is an aminoterminal Aβ1-7 peptide conjugate. Vanutide cridificar can be used for Alzheimer's disease (AD) research.
    Vanutide cridificar
  • HY-P99825
    Relfovetmab 2171034-70-9
    Relfovetmab is an anti-NGF monoclonal antibody (mAb).
    Relfovetmab
  • HY-U00001
    Phenglutarimid 1156-05-4 98%
    Phenglutarimid is an anticholinergic used as an antiparkinsonian agent.
    Phenglutarimid
Cat. No. Product Name / Synonyms Application Reactivity